Research of Numerical Simulation of Biomechanics on In-stent-restenosis

Stenting intervention is emerging as an alternative for treating the stenosis of cardiac and cerebral arteries. However, postoperative In-Stent-Restenosis (ISR) remains a challenge for medical sciences and biomechanical engineering. ISR is related not only to the stress induced by the mechanical support of stent struts on arterial wall, but also to the intimal hyperplasia induced by the hemodynamic changes. The recent research on biomechanics of stented artery was reviewed in this paper. In particular, from the perspectives of solid mechanics and hemodynamics, the research progress of stented artery using biomechanical simulation was discussed. The biomechanical factors associated with ISR were analyzed and summarized. Numerical simulation is a powerful approach for the investigation of the relationship between stenting intervention and ISR, and can provide scientific guidelines for the design of stent structure and clinical procedure of stenting intervention.